Invention Grant
US08524750B2 (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds
失效
（吡唑-3-基）-1,3,4-噻二唑-2-胺和（吡唑-3-基）-1,3,4-噻唑-2-胺化合物
- Patent Title: (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds
- Patent Title (中): （吡唑-3-基）-1,3,4-噻二唑-2-胺和（吡唑-3-基）-1,3,4-噻唑-2-胺化合物
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Application No.: US13264169Application Date: 2010-04-13
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Publication No.: US08524750B2Publication Date: 2013-09-03
- Inventor: Lluis Ballell Pages , Julia Castro Pichel , Raquel Fernandez Menendez , Esther Pilar Fernandez Velando , Silvia Gonzalez Del Valle , Maria Luisa Leon Diaz , Alfonso Mendoza Losana , Matthew James Wolfendale
- Applicant: Lluis Ballell Pages , Julia Castro Pichel , Raquel Fernandez Menendez , Esther Pilar Fernandez Velando , Silvia Gonzalez Del Valle , Maria Luisa Leon Diaz , Alfonso Mendoza Losana , Matthew James Wolfendale
- Applicant Address: GB Brentford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Brentford, Middlesex
- Agent Bonnie L. Deppenbrock
- Priority: EP09382049 20090413
- International Application: PCT/EP2010/002265 WO 20100413
- International Announcement: WO2010/118852 WO 20101021
- Main IPC: A61K31/433
- IPC: A61K31/433 ; A61K31/427 ; A61K31/4155 ; C07D285/135 ; C07D231/16 ; C07D417/14
Abstract:
A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
Public/Granted literature
- US20120095064A1 (PYRAZOL-3-YL)-1,3,4-THIADIAZOL-2-AMINE AND (PYRAZOL-3-YL)-1,3,4-THIAZOL-2-AMINE COMPOUNDS Public/Granted day:2012-04-19
Information query
