Invention Grant
US08524769B2 Process for producing a fraction enriched up to 100% of 3-O-acetyl-11-keto-beta-boswellic acid from an extract containing a mixture of boswellic acids
有权
从含有乳糖酸的混合物的提取物中生产富含高达100％的3-O-乙酰基-11-酮-β-保乳酸的级分的方法
- Patent Title: Process for producing a fraction enriched up to 100% of 3-O-acetyl-11-keto-beta-boswellic acid from an extract containing a mixture of boswellic acids
- Patent Title (中): 从含有乳糖酸的混合物的提取物中生产富含高达100％的3-O-乙酰基-11-酮-β-保乳酸的级分的方法
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Application No.: US10432058Application Date: 2002-03-05
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Publication No.: US08524769B2Publication Date: 2013-09-03
- Inventor: Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Sridhar Pratha
- Applicant: Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Subbaraju Gottumukkala , Trimurtulu Golakoti , Sridhar Pratha
- Applicant Address: IN Vijayawada
- Assignee: Laila Impex
- Current Assignee: Laila Impex
- Current Assignee Address: IN Vijayawada
- Agency: Kramer / Amado, P.C.
- International Application: PCT/IN02/00034 WO 20020305
- International Announcement: WO03/074063 WO 20030912
- Main IPC: A61K31/21
- IPC: A61K31/21
Abstract:
The invention relates to a process for producing a fraction enriched upto 100% of 3-O-acetyl-11-keto-β-boswellic acid. An organic solvent extract of gum resin from Boswellia species is first subjected to oxidation and then acetylation or vice versa. This converts the less potent boswellic acids present in the fraction to AKBA. This treated fraction is subjected to further purification and separation by chromatographic separation techniques to enhance its purity and to remove contaminants therefrom. This process provide an access to a fraction enriched in 10-100% AKBA for therapeutic applications.
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