Invention Grant
US08524781B2 Organosulfur compounds, a method of making organosulfur compounds and their use for inhibiting the growth of tumour cells
失效
有机硫化合物,一种制备有机硫化合物的方法及其用于抑制肿瘤细胞生长的用途
- Patent Title: Organosulfur compounds, a method of making organosulfur compounds and their use for inhibiting the growth of tumour cells
- Patent Title (中): 有机硫化合物,一种制备有机硫化合物的方法及其用于抑制肿瘤细胞生长的用途
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Application No.: US13057960Application Date: 2009-08-05
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Publication No.: US08524781B2Publication Date: 2013-09-03
- Inventor: Catherine Hart Kaschula , Roger Hunter , Mohamed Iqbal Parker
- Applicant: Catherine Hart Kaschula , Roger Hunter , Mohamed Iqbal Parker
- Applicant Address: ZA Cape Town
- Assignee: University of Cape Town
- Current Assignee: University of Cape Town
- Current Assignee Address: ZA Cape Town
- Agency: Frommer Lawrence & Haug LLP
- Agent Ronald R. Santucci
- Priority: ZA2008/06780 20080805
- International Application: PCT/IB2009/053399 WO 20090805
- International Announcement: WO2010/016011 WO 20100211
- Main IPC: A61K31/105
- IPC: A61K31/105 ; C07C325/02

Abstract:
Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumor cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.
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