Invention Grant
- Patent Title: Key intermediate for the preparation of Stilbenes, solid forms of Pterostilbene, and methods for making the same
- Patent Title (中): 二苯乙烯制备的主要中间体，芪二烯的固体形式及其制备方法
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Application No.: US13011593Application Date: 2011-01-21
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Publication No.: US08524782B2Publication Date: 2013-09-03
- Inventor: Gottumukkala V. Subbaraju , Masna Mahesh , Hindupur R. Mohan , Thatipally Suresh , Igor Ivanisevic , Mark Andres , Kyle Stephens
- Applicant: Gottumukkala V. Subbaraju , Masna Mahesh , Hindupur R. Mohan , Thatipally Suresh , Igor Ivanisevic , Mark Andres , Kyle Stephens
- Applicant Address: IN
- Assignee: Laurus Labs Private Limited
- Current Assignee: Laurus Labs Private Limited
- Current Assignee Address: IN
- Agency: Blank Rome LLP
- Priority: IN1766/CHE/2008 20080723; IN741/CHE/2010 20100322
- Main IPC: A01N31/14
- IPC: A01N31/14 ; A61K31/075
Abstract:
The present invention provides a scalable process for the preparation of stilbenes by (i) condensing 3,5-dialkylbenzyl phosphonates with 4′-O-tetrahydropyranyl benzaldehyde to get 3,5-alkyl-4′-O-tetrahydropyranyl Stilbene and (ii) deprotecting the obtained 3,5-Dialkyl-4′-O-tetrahydropyranylstilbene to yield stilbenes. The present invention also provides a novel intermediate 3,5-Dialkyl-4′-O-tetrahydropyranyl stilbene, which is a key intermediate for the synthesis of stilbenes such as Pterostilbene and Resveratrol. The present invention also provides characteristics of various solid forms of Pterostilbene, methods for their preparation, as well as dosage forms containing the same for administration to or consumption by humans.
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