Invention Grant
US08524876B2 RNAi molecule targeting thymidylate synthase and application thereof
有权
靶向胸苷酸合酶的RNAi分子及其应用
- Patent Title: RNAi molecule targeting thymidylate synthase and application thereof
- Patent Title (中): 靶向胸苷酸合酶的RNAi分子及其应用
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Application No.: US13258591Application Date: 2010-03-29
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Publication No.: US08524876B2Publication Date: 2013-09-03
- Inventor: Hiromi Wada , Cheng Long Huang
- Applicant: Hiromi Wada , Cheng Long Huang
- Applicant Address: JP Tokushima-Shi
- Assignee: Delta-Fly Pharma, Inc.
- Current Assignee: Delta-Fly Pharma, Inc.
- Current Assignee Address: JP Tokushima-Shi
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2009-086463 20090331
- International Application: PCT/JP2010/055521 WO 20100329
- International Announcement: WO2010/113844 WO 20101007
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
This invention provides a novel RNAi molecule that can significantly potentiate antitumor effects of a 5-FU antitumor agent. The RNAi molecule comprises the nucleotide sequence shown in SEQ ID NO: 2. The invention also provides an antitumor agent comprising such RNAi molecule and a 5-FU antitumor agent.
Public/Granted literature
- US20120016012A1 RNAi MOLECULE TARGETING THYMIDYLATE SYNTHASE AND APPLICATION THEREOF Public/Granted day:2012-01-19
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