Invention Grant
US08524877B2 Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in-situ analysis
有权
标记用于原位分析的寡核苷酸探针和蛋白质的寡核苷酸序列配方
- Patent Title: Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in-situ analysis
- Patent Title (中): 标记用于原位分析的寡核苷酸探针和蛋白质的寡核苷酸序列配方
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Application No.: US13536021Application Date: 2012-06-28
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Publication No.: US08524877B2Publication Date: 2013-09-03
- Inventor: Joseph G. Utermohlen , John F. Connaughton
- Applicant: Joseph G. Utermohlen , John F. Connaughton
- Applicant Address: US AZ Tucson
- Assignee: Ventana Medical Systems, Inc.
- Current Assignee: Ventana Medical Systems, Inc.
- Current Assignee Address: US AZ Tucson
- Agency: Klarquist Sparkman, LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/02
Abstract:
The present invention provides oligonucleotide probes and oligonucleotide probe collections for detecting or localizing a plurality nucleic acid target genes within a cell or tissue sample. Specifically, the invention provides collections of oligonucleotide probes for use in in situ hybridization analyses in which each probe has a label-domain with the sequence formulas of (CTATTTT)nCT, (AAAATAG)n or (TTTTATC)n or (GATAAAA)n in which all cases “n” would equal 1 or greater. The present invention also provides collections or “cocktails” of oligonucleotide probes for detecting or localizing specific nucleic acid target genes within a cell or tissue sample.
Public/Granted literature
- US20120309951A1 OLIGONUCLEOTIDE SEQUENCE FORMULA FOR LABELING OLIGONUCLEOTIDE PROBES AND PROTEINS FOR IN-SITU ANALYSIS Public/Granted day:2012-12-06
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