Invention Grant
US08524917B2 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
失效
具有鞘氨醇-1-磷酸（S1P）受体拮抗剂生物活性的6-取代吲哚-3-羧酸酰胺化合物
- Patent Title: 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
- Patent Title (中): 具有鞘氨醇-1-磷酸（S1P）受体拮抗剂生物活性的6-取代吲哚-3-羧酸酰胺化合物
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Application No.: US12013239Application Date: 2008-01-11
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Publication No.: US08524917B2Publication Date: 2013-09-03
- Inventor: Richard L. Beard , Haiqing Yuan , John E. Donello , Xiaoxia Liu , Tien Duong
- Applicant: Richard L. Beard , Haiqing Yuan , John E. Donello , Xiaoxia Liu , Tien Duong
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Doina G. Ene
- Main IPC: A61K31/444
- IPC: A61K31/444 ; A61K31/4439 ; A61K31/404 ; C07D209/42 ; C07D401/14 ; C07D401/12 ; C07D401/06
Abstract:
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity: and wherein the variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
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