Invention Grant
- Patent Title: Manufacturing process for sitagliptin from L-aspartic acid
- Patent Title (中): 来自L-天冬氨酸的西他列汀的制备方法
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Application No.: US13068713Application Date: 2011-05-18
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Publication No.: US08524936B2Publication Date: 2013-09-03
- Inventor: Milan Soukup
- Applicant: Milan Soukup
- Main IPC: C07C269/00
- IPC: C07C269/00 ; C07C227/10
Abstract:
The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as oral anti-diabetic drug. Starting from L-aspartic acid derivate of formula IV the invention describes preparation of the chiral (R)-β-amino acid of formula II known as a precursor in the synthesis of Sitagliptin (formula I).
Public/Granted literature
- US20120123144A1 Manufacturing process for sitagliptin from L-aspartic acid Public/Granted day:2012-05-17
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