Invention Grant
US08524946B2 Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent
有权
氟硼化合物，由其制成的芳环的氨基甲基化剂，以及使用氨基甲基化试剂的含氨基甲基芳环的化合物的制备方法
- Patent Title: Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent
- Patent Title (中): 氟硼化合物，由其制成的芳环的氨基甲基化剂，以及使用氨基甲基化试剂的含氨基甲基芳环的化合物的制备方法
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Application No.: US13238571Application Date: 2011-09-21
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Publication No.: US08524946B2Publication Date: 2013-09-03
- Inventor: Keigo Tanaka
- Applicant: Keigo Tanaka
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2006-190813 20060711
- Main IPC: C07F5/02
- IPC: C07F5/02
Abstract:
A production method of a compound containing a primary, secondary, or tertiary aminomethyl aromatic ring of the present invention includes: using a fluoroboron compound or a dimer thereof, or solvates thereof, which are represented by a formula (I): Ra(Rb)N—CH2—BF3M (I) as an aminomethylating agent for an aromatic ring; and reacting the aminomethylating agent with an aromatic ring-containing compound, which can react with the aminomethylating agent, under the presence of a metal catalyst such as a palladium compound so as to perform the direct aminomethylation of the aromatic ring.
Public/Granted literature
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