Systems and methods are operable to initiate a pairing process and a de-pairing process between a controlled device and a radio frequency (RF) remote control. An exemplary embodiment detects presence of a radio frequency identifier (RFID) tag in an interrogation zone established by an RFID tag reader, automatically initiates a pairing process in response to detecting the presence of the RFID tag in the interrogation zone, and completes the pairing process between the RF remote control and the controlled device, wherein the pairing process identifies a unique identifier associated with the RF remote control. A subsequently received RF signal emitted by the RF remote control includes at least one command configured to control operation of the controlled device and includes the unique identifier.