A signal separation device includes a column switching unit switching a column vector of a channel matrix obtained by estimating a propagation path characteristic so that a transmitted signal component of each transmit antenna is in a left end, a QR decomposition layering unit multiplying received signals by an output from the column switching unit, and outputting a received signal vector in which the received signal is layered so that a transmitted signal exists in a first row, an interference cancellation unit cancelling an interference component from a signal in the first row by using a signal other than the signal in the first row, a signal candidate point selecting unit selecting a prescribed number of signal candidate points from among signals output by the interference cancellation unit, and a signal separation unit separating the transmitted signal from the layered received signal vector using the selected signal candidate point.