According to some embodiments, a mobile device may calculate adjustments of a timing advance based on a determined relative downlink timing change. Adjustments of the timing advance may be made toward a target timing advance in accordance with an adjustment parameter. The adjustment parameter may be adapted based on a received timing advance command and at least one of: a calculated adjustment of the timing advance; and a difference between the target timing advance and the timing advance. In another aspect, self-adjustment of a timing advance performed by a mobile device may be configured based on a property of a communication channel between the mobile device and a base station. In another aspect, self-adjustment of a timing advance performed by a mobile device may be configured based on timing advance commands received from a base station.