Disclosed herein is a method of accessing a slave device from a circuit including a central processing unit, a data transfer engine, and an interface to the slave device. In one embodiment, the method includes: executing code on the central processing unit to set up the data transfer engine to access the slave device; and based on the set-up, operating the data transfer engine to supply a read request word to a transmit buffer of the interface for transmission to the slave device, and, after return of a corresponding response word to a first-in-first-out receive buffer of the interface, to disable the first-in-first-out receive buffer from receiving any further data such that the last word therein is assured to be the response word. The method further includes using an underflow mechanism of the first-in-first-out receive buffer to determine the last word therein and hence determine the response word.