A method of delivering medication to a patient includes inserting a medication administration device into a rectum of the patient, inflating a balloon of the medication administration device to retain the medication administration device in the rectum, delivering a first dose of a medication through the medication administration device such that the first dose of medication is applied to a distal portion of the rectum, delivering a second dose of a medication through the medication administration device such that the second dose of medication is applied to the distal portion of the rectum, and leaving the medication administration device in the rectum until it is dislodged for defecation. The first and second doses are delivered without removing the medication administration device from the rectum between doses.