Invention Grant
- Patent Title: Process for production of spherical microparticles comprising tamsulosin hydrochloride
- Patent Title (中): 包含盐酸坦洛新的球形微粒的生产方法
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Application No.: US13001393Application Date: 2009-06-29
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Publication No.: US08529953B2Publication Date: 2013-09-10
- Inventor: Toshihiro Yanagi , Yoshitaka Iwakura , Hisaya Sangawa , Yasufumi Okamura
- Applicant: Toshihiro Yanagi , Yoshitaka Iwakura , Hisaya Sangawa , Yasufumi Okamura
- Applicant Address: JP Osaka
- Assignee: Sawai Pharmaceutical Co., Ltd.
- Current Assignee: Sawai Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JP2008-172828 20080701
- International Application: PCT/JP2009/002981 WO 20090629
- International Announcement: WO2010/001574 WO 20100107
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/20 ; A61K9/00 ; A61K31/18
Abstract:
The present invention provides a method for producing spherical fine particles containing tamsulosin hydrochloride, the method includes the steps of: (1) mixing and stirring tamsulosin hydrochloride (a), microcrystalline cellulose (b), and water until a mixture of the component (a) and the component (b) is uniformly impregnated with the water; (2) granulating the mixture obtained in step (1) using an stirring granulator whose peripheral speed is set to be 5.5 to 9.0 m/s; and (3) drying the granules obtained in step (2). The present invention also provides spherical fine particles obtained according to the method, coated fine particles obtained by applying a coating to the spherical fine particles, and an orally disintegrating tablet containing the coated fine particles.
Public/Granted literature
- US20110104270A1 PROCESS FOR PRODUCTION OF SPHERICAL MICROPARTICLES COMPRISING TAMSULOSIN HYDROCHLORIDE Public/Granted day:2011-05-05
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