Invention Grant
US08530200B2 Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same
有权
用于增强5'-鸟苷一磷酸生产力的棒状杆菌菌株和使用其制备5'-鸟苷酸单磷酸的方法
- Patent Title: Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same
- Patent Title (中): 用于增强5'-鸟苷一磷酸生产力的棒状杆菌菌株和使用其制备5'-鸟苷酸单磷酸的方法
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Application No.: US13140302Application Date: 2009-12-17
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Publication No.: US08530200B2Publication Date: 2013-09-10
- Inventor: Jinman Cho , Hye Won Kim , Yoon Seok Oh , Jang Hee Park
- Applicant: Jinman Cho , Hye Won Kim , Yoon Seok Oh , Jang Hee Park
- Applicant Address: KR Seoul
- Assignee: CJ Cheiljedang Corporation
- Current Assignee: CJ Cheiljedang Corporation
- Current Assignee Address: KR Seoul
- Agency: Lathrop & Gage LLP
- Agent Brian C. Trinque; Michael Biro
- Priority: KR10-2008-0128846 20081217
- International Application: PCT/KR2009/007558 WO 20091217
- International Announcement: WO2010/071366 WO 20100624
- Main IPC: C12P19/32
- IPC: C12P19/32 ; C12P19/30
Abstract:
Disclosed is a method of producing 5′-guanosine monophosphate using a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type, thereby showing improved ATP productivity. Also, a novel microorganism is disclosed. The method comprises: culturing the corynebacteria strain which is enhanced in malate dehydrogenase activity over the endogenous activity, thus producing ATP in high yield; producing XMP in the culture; adding to the culture an enzyme or microorganism having XMP amination activity; and obtaining GMP from the culture.
Public/Granted literature
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