Invention Grant
US08530236B2 Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
有权
可溶胀的（甲基）丙烯酸酯表面用于在化学上限定的培养基中培养细胞
- Patent Title: Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
- Patent Title (中): 可溶胀的（甲基）丙烯酸酯表面用于在化学上限定的培养基中培养细胞
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Application No.: US13668867Application Date: 2012-11-05
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Publication No.: US08530236B2Publication Date: 2013-09-10
- Inventor: Andrei Gennadyevich Fadeev , Arthur Winston Martin , Zara Melkoumian , Christopher Bankole Shogbon , David Michael Weber , Jennifer Lynn Weber , Yue Zhou
- Applicant: Andrei Gennadyevich Fadeev , Arthur Winston Martin , Zara Melkoumian , Christopher Bankole Shogbon , David Michael Weber , Jennifer Lynn Weber , Yue Zhou
- Applicant Address: US NY Corning
- Assignee: Corning Incorporated
- Current Assignee: Corning Incorporated
- Current Assignee Address: US NY Corning
- Agent Susan S. Wilks
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N11/00
Abstract:
Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol)dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.
Public/Granted literature
- US20130203165A1 SWELLABLE (METH)ACRYLATE SURFACES FOR CULTURING CELLS IN CHEMICALLY DEFINED MEDIA Public/Granted day:2013-08-08
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