Invention Grant
- Patent Title: Sonic hedgehog modulators
- Patent Title (中): 声波刺猬调制器
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Application No.: US12988755Application Date: 2009-04-21
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Publication No.: US08530456B2Publication Date: 2013-09-10
- Inventor: Lee F. Peng , Julia Lamenzo , Nicole Maloof , Kazuo Nakai , Benjamin Stanton , Sara Jean Buhrlage , Lawrence MacPherson , Michel Weiwer , Stuart L. Schreiber
- Applicant: Lee F. Peng , Julia Lamenzo , Nicole Maloof , Kazuo Nakai , Benjamin Stanton , Sara Jean Buhrlage , Lawrence MacPherson , Michel Weiwer , Stuart L. Schreiber
- Applicant Address: US MA Cambridge US MA Cambridge US MA Boston
- Assignee: President and Fellows of Harvard College,Massachusetts Institute of Technology,The General Hospital Corporation
- Current Assignee: President and Fellows of Harvard College,Massachusetts Institute of Technology,The General Hospital Corporation
- Current Assignee Address: US MA Cambridge US MA Cambridge US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Agent C. Hunter Baker
- International Application: PCT/US2009/041295 WO 20090421
- International Announcement: WO2009/132032 WO 20091029
- Main IPC: C07D495/06
- IPC: C07D495/06 ; C07D493/06 ; C07D495/16 ; C07D493/16 ; A61K31/395 ; A61P35/00
Abstract:
The present invention relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.
Public/Granted literature
- US20110172233A1 SONIC HEDGEHOG MODULATORS Public/Granted day:2011-07-14
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