Invention Grant
- Patent Title: Method for the treatment of lymphangioleiomyomatosis (LAM)
- Patent Title (中): 淋巴管平滑肌瘤病（LAM）治疗方法
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Application No.: US12989529Application Date: 2009-05-20
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Publication No.: US08530457B2Publication Date: 2013-09-10
- Inventor: Elizabeth Petri Henske , Jane Yu
- Applicant: Elizabeth Petri Henske , Jane Yu
- Applicant Address: US PA Philadelphia
- Assignee: Fox Chase Cancer Center
- Current Assignee: Fox Chase Cancer Center
- Current Assignee Address: US PA Philadelphia
- Agency: Dann, Dorfman, Herrell and Skillman, P.C.
- Agent Patrick J. Hagan
- International Application: PCT/US2009/044643 WO 20090520
- International Announcement: WO2009/143224 WO 20091126
- Main IPC: A01N37/28
- IPC: A01N37/28 ; A01N37/18 ; A61K31/33 ; A61K31/19 ; A61K31/16 ; A61K31/165
Abstract:
Treatment of lymphangioleiomyomatosis with the MEK1/2 inhibitor CI-1040 delayed the development of primary tumors and blocked the estrogen-induced lung metastases in treated animals. Such treatment also reduced the number of circulating ELT3 cells and decreased their lung colonization after intravenous injection.
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