Invention Grant
US08530473B2 Tetrahydroquinoxaline urea derivatives as modulators of 11β-hydroxysteroid dehydrogenase type 1
有权
四氢喹喔啉脲衍生物作为1型11β-羟基类固醇脱氢酶的调节剂
- Patent Title: Tetrahydroquinoxaline urea derivatives as modulators of 11β-hydroxysteroid dehydrogenase type 1
- Patent Title (中): 四氢喹喔啉脲衍生物作为1型11β-羟基类固醇脱氢酶的调节剂
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Application No.: US13386827Application Date: 2010-07-23
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Publication No.: US08530473B2Publication Date: 2013-09-10
- Inventor: Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Olivier Venier
- Applicant: Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Olivier Venier
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: FR0903687 20090727
- International Application: PCT/FR2010/051564 WO 20100723
- International Announcement: WO2011/012801 WO 20110203
- Main IPC: A61K31/495
- IPC: A61K31/495
Abstract:
The invention relates to a compound of the general formula (I), as defined herein which is useful in modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are useful for treating pathologies in which such modulation is beneficial, as in the case of metabolic syndrome or of noninsulin-dependent type 2 diabetes. The invention also relates to pharmaceutical preparations containing such a compound, processes for preparing and intermediates useful in the preparation of a such a compound.
Public/Granted literature
- US20120135958A1 TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF Public/Granted day:2012-05-31
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