Invention Grant
US08530490B2 Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity
有权
具有人脱氧尿苷三磷酸酶抑制活性的尿嘧啶化合物或其盐
- Patent Title: Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity
- Patent Title (中): 具有人脱氧尿苷三磷酸酶抑制活性的尿嘧啶化合物或其盐
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Application No.: US12996079Application Date: 2009-06-02
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Publication No.: US08530490B2Publication Date: 2013-09-10
- Inventor: Masayoshi Fukuoka , Tatsushi Yokogawa , Seiji Miyahara , Hitoshi Miyakoshi , Wakako Yano , Junko Taguchi , Yayoi Takao
- Applicant: Masayoshi Fukuoka , Tatsushi Yokogawa , Seiji Miyahara , Hitoshi Miyakoshi , Wakako Yano , Junko Taguchi , Yayoi Takao
- Applicant Address: JP Tokyo
- Assignee: Taiho Pharmaceutical Co., Ltd.
- Current Assignee: Taiho Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2008-146334 20080603
- International Application: PCT/JP2009/002481 WO 20090602
- International Announcement: WO2009/147843 WO 20091210
- Main IPC: A61K31/505
- IPC: A61K31/505 ; C07D401/02 ; C07D239/02

Abstract:
Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug.A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.
Public/Granted literature
- US20110082163A1 NOVEL URACIL COMPOUND OR SALT THEREOF HAVING HUMAN DEOXYURIDINE TRIPHOSPHATASE INHIBITORY ACTIVITY Public/Granted day:2011-04-07
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