Invention Grant
- Patent Title: Broad spectrum gram-positive antimicrobials and anthelmintics with efficacy against drug-resistant strains and Mycobacterium species
- Patent Title (中): 广谱革兰阳性抗菌药物和驱虫药具有抗药性和分枝杆菌的功效
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Application No.: US12973078Application Date: 2010-12-20
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Publication No.: US08530512B2Publication Date: 2013-09-10
- Inventor: Aaron P. Monte , M. Shahjahan Kabir , Marc A. Rott , William R. Schwan , James M. Cook, III , Jennifer A. Miskowski , Ranjit Verma , Leah Defoe
- Applicant: Aaron P. Monte , M. Shahjahan Kabir , Marc A. Rott , William R. Schwan , James M. Cook, III , Jennifer A. Miskowski , Ranjit Verma , Leah Defoe
- Agency: Boyle Fredrickson, S.C.
- Main IPC: A61K31/38
- IPC: A61K31/38 ; A61K31/34 ; A61K31/404

Abstract:
The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present and when x=0, W is not phenyl.
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