Invention Grant
- Patent Title: Enzyme inhibiting compounds
- Patent Title (中): 酶抑制化合物
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Application No.: US12939556Application Date: 2010-11-04
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Publication No.: US08530653B2Publication Date: 2013-09-10
- Inventor: Michael J. Roberts
- Applicant: Michael J. Roberts
- Applicant Address: US NC Charlotte
- Assignee: Chelsea Therapeutics, Inc.
- Current Assignee: Chelsea Therapeutics, Inc.
- Current Assignee Address: US NC Charlotte
- Agency: Womble Carlyle Sandridge & Rice, LLP
- Main IPC: C07D239/72
- IPC: C07D239/72 ; C07D487/00 ; A01N43/54 ; A01N43/90
Abstract:
The present invention is directed to compounds that are specifically structured to provide enzyme inhibition. In specific embodiments, the enzyme inhibiting compounds exhibit antifolate activity. Particularly, the inventive compounds are formed of an antifolate residue that is active in inhibiting one or more of TS, DHFR, GAR, FPGS, and AICAR Tfase. The enzyme inhibiting compounds are useful in a variety of methods of treatment, including treating abnormal cell proliferation and treating inflammation.
Public/Granted literature
- US20110112126A1 ENZYME INHIBITING COMPOUNDS Public/Granted day:2011-05-12
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