A mixed-signal adaptive integrated circuit may comprise a primary function circuit, a digitally controlled analog sub-system cooperatively connected with the primary function circuit, and an on-chip signal analyzer. The on-chip signal analyzer may be arranged to analyze RF signals. The signal analyzer may comprise at least one multiplexor for selecting selected RF signals for comparison and analysis, and may comprise a digital signal processor (DSP) for analyzing the selected RF signals and adjusting at least one operational parameter of the digitally controlled analog sub-system responsive to the analysis.