Systems and methods for accelerating stream cipher encryption operations are described. In one aspect, a computer-implemented method receives data. The method separates the data into multiple file chunks for compression. A respective compression-encryption instructions header is provided for each compressed file chunk. Each compressed file chunk then is encrypted according to corresponding encryption instructions in the file-chunk's compression-encryption instructions. In one implementation, the compressed file chunks are encrypted by respective worker nodes in a peer-to-peer computing environment. The compressed and encrypted file chunks are merged into a single encrypted-compressed-merged file.