Hydraulic vitrectomy probes and methods and systems associated therewith are discussed. Example hydraulic vitrectomy probes may include a pressure multiplier that is operable to output a hydraulic pressure at a multiple of a received pneumatic pressure. Because of the incompressible nature of liquid, hydraulic vitrectomy probes are, among other things, more responsive, may be operated at higher cutting rates, provide improved patient safety, and have a form factor (e.g., size and/or shape) that may be more easily maneuvered by a surgeon.