Invention Grant
US08540982B2 Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity
有权
诱导自然杀伤（NK）细胞介导的免疫应答和增加NK细胞活性的方法
- Patent Title: Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity
- Patent Title (中): 诱导自然杀伤（NK）细胞介导的免疫应答和增加NK细胞活性的方法
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Application No.: US13443703Application Date: 2012-04-10
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Publication No.: US08540982B2Publication Date: 2013-09-24
- Inventor: Nadeem Sheikh , Lori Jones
- Applicant: Nadeem Sheikh , Lori Jones
- Applicant Address: US WA Seattle
- Assignee: Dendreon Corporation
- Current Assignee: Dendreon Corporation
- Current Assignee Address: US WA Seattle
- Agency: King & Spalding LLP
- Agent Peter J. Dehlinger
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K35/14 ; G01N33/48 ; G01N33/50
Abstract:
This disclosure relates to methods of inducing a natural killer (NK) cell-mediated immune response and increasing NK activity in a mammal for the treatment of tumors and virus infections, comprising isolating peripheral blood mononuclear cells (PBMCs) from a subject, exposing them in vitro to a protein conjugate comprising granulocyte macrophage colony stimulating factor (GM-CSF) covalently linked to a soluble peptide antigen to activate the PBMCs, and administering the activated PBMCs to the subject. The method also relates to assessing NK cell activity of activated PBMCs to determine whether the subject has had a therapeutically effective response to the protein conjugate.
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