Invention Grant
US08540987B2 Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody
有权
用于中和A型肉毒杆菌毒素和A型抗人类肉毒毒素毒素的组合物
- Patent Title: Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody
- Patent Title (中): 用于中和A型肉毒杆菌毒素和A型抗人类肉毒毒素毒素的组合物
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Application No.: US12864018Application Date: 2009-01-23
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Publication No.: US08540987B2Publication Date: 2013-09-24
- Inventor: Masachika Azuma , Motohide Takahashi , Shunji Kozaki , Masafumi Mukamoto , Tomoko Kohda , Gene Kurosawa , Yoshikazu Kurosawa
- Applicant: Masachika Azuma , Motohide Takahashi , Shunji Kozaki , Masafumi Mukamoto , Tomoko Kohda , Gene Kurosawa , Yoshikazu Kurosawa
- Applicant Address: JP Nagoya-shi JP Tokyo JP Sakai-shi
- Assignee: Institute for Antibodies Co., Ltd.,Japan as Represented by Director-General of National Institute of Infectious Diseases,Osaka Prefecture University Public Corporation
- Current Assignee: Institute for Antibodies Co., Ltd.,Japan as Represented by Director-General of National Institute of Infectious Diseases,Osaka Prefecture University Public Corporation
- Current Assignee Address: JP Nagoya-shi JP Tokyo JP Sakai-shi
- Agency: Edwards Wildman Palmer LLP
- Agent James E. Armstrong, IV; Edmund J. Koundakjian
- Priority: JP2008-017152 20080129
- International Application: PCT/JP2009/000250 WO 20090123
- International Announcement: WO2009/096162 WO 20090806
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/00 ; C07K16/00 ; C12P21/08
Abstract:
Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.
Public/Granted literature
- US20110014211A1 COMPOSITION FOR NEUTRALIZING BOTULINUS TOXIN TYPE-A, AND HUMAN ANTI-BOTULINUS TOXIN TYPE-A ANTIBODY Public/Granted day:2011-01-20
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