Invention Grant
US08541197B2 Targets, including Yap1, for antifungal drug discovery and therapy
失效
目标，包括Yap1，用于抗真菌药物的发现和治疗
- Patent Title: Targets, including Yap1, for antifungal drug discovery and therapy
- Patent Title (中): 目标，包括Yap1，用于抗真菌药物的发现和治疗
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Application No.: US12517971Application Date: 2007-12-10
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Publication No.: US08541197B2Publication Date: 2013-09-24
- Inventor: Reeta Prusty Rao , Samuel Michael Politz
- Applicant: Reeta Prusty Rao , Samuel Michael Politz
- Applicant Address: US MA Worcester
- Assignee: Worcester Polytechnic Institute
- Current Assignee: Worcester Polytechnic Institute
- Current Assignee Address: US MA Worcester
- Agency: Duane Morris LLP
- International Application: PCT/US2007/086998 WO 20071210
- International Announcement: WO2008/073900 WO 20080619
- Main IPC: C12Q1/18
- IPC: C12Q1/18 ; C12Q1/02
Abstract:
The present invention is based on the discovery of a two organism model system that can be used to identify virulence factors. The system is also useful in the process of drug delivery. More specifically, we have established valid fungal infection in caenorhabditis elegans with an invading pathogen, the yeast Saccharomyces cerevisiae. Because both species are genetic model organisms, the assay can be used to identify host and virulence factors involved in such interactions.
Public/Granted literature
- US20110033442A1 TARGETS, INCLUDING YAP1, FOR ANTIFUNGAL DRUG DISCOVERY AND THERAPY Public/Granted day:2011-02-10
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