Invention Grant
- Patent Title: Mutant penicillin G acylases
- Patent Title (中): 突变型青霉素G酰基转移酶
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Application No.: US13141877Application Date: 2009-12-22
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Publication No.: US08541199B2Publication Date: 2013-09-24
- Inventor: Jan Metske Van Der Laan , Harold Monro Moody , Richard Kerkman , Thomas Van Der Does
- Applicant: Jan Metske Van Der Laan , Harold Monro Moody , Richard Kerkman , Thomas Van Der Does
- Applicant Address: NL Delft
- Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
- Current Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
- Current Assignee Address: NL Delft
- Agency: Nixon & Vanderhye P.C.
- Priority: EP08172831 20081223
- International Application: PCT/EP2009/067752 WO 20091222
- International Announcement: WO2010/072765 WO 20100701
- Main IPC: C12P1/00
- IPC: C12P1/00 ; C12N9/84 ; C12N1/20 ; C07H21/04
Abstract:
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected from the group consisting of amino acid positions A3, A77, A90, A144 A192, B24, B109, B148, B313, B460 and B488 according to the amino acid numbering of the Escherichia coli penicillin G acylase having the amino acid sequence depicted in SEQ ID No: 1.
Public/Granted literature
- US20110256585A1 MUTANT PENICILLIN G ACYLASES Public/Granted day:2011-10-20
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