Invention Grant
US08541448B2 Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
有权
用于抑制NHE介导的止痒剂用于治疗与流体保留或盐过载和胃肠道疾病相关的疾病的化合物和方法
- Patent Title: Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
- Patent Title (中): 用于抑制NHE介导的止痒剂用于治疗与流体保留或盐过载和胃肠道疾病相关的疾病的化合物和方法
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Application No.: US13172394Application Date: 2011-06-29
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Publication No.: US08541448B2Publication Date: 2013-09-24
- Inventor: Dominique Charmot , Jeffrey W. Jacobs , Michael Robert Leadbetter , Marc Navre , Christopher Carreras , Noah Bell
- Applicant: Dominique Charmot , Jeffrey W. Jacobs , Michael Robert Leadbetter , Marc Navre , Christopher Carreras , Noah Bell
- Applicant Address: US CA Fremont
- Assignee: Ardelyx, Inc.
- Current Assignee: Ardelyx, Inc.
- Current Assignee Address: US CA Fremont
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/47 ; C07D217/00 ; C07D217/02
Abstract:
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.
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Information query
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