Invention Grant
US08541585B2 N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof
有权
N-酰基环胺衍生物或其药学上可接受的盐
- Patent Title: N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof
- Patent Title (中): N-酰基环胺衍生物或其药学上可接受的盐
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Application No.: US13505161Application Date: 2011-03-11
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Publication No.: US08541585B2Publication Date: 2013-09-24
- Inventor: Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
- Applicant: Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
- Applicant Address: JP Osaka
- Assignee: Dainippon Sumitomo Pharma Co., Ltd.
- Current Assignee: Dainippon Sumitomo Pharma Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2010-054177 20100311; JP2010-285844 20101222
- International Application: PCT/JP2011/056497 WO 20110311
- International Announcement: WO2011/111875 WO 20110915
- Main IPC: C07D401/00
- IPC: C07D401/00 ; A61K31/44

Abstract:
The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurological diseases associated with cognitive dysfunction other than schizophrenia. N-Acyl cyclic amine derivatives of formula (1): wherein Ar1 and Ar2 are aryl or heteroaryl; V is nitrogen, or CR3; W1 is a single bond, —C(O)—, etc.; W2 is C1-alkylene; W3 is a single bond, methylene, —NH—, —CR4═CR5—, etc.; Ring Q is a group of formula (a) in which n is 0 or 1; m is 0 to 2; k is 1 to 3; Z is a single bond, methylene, oxygen, etc.; R1a, R1b and R1c are each, same or different, hydrogen, hydroxyl, halogen, cyano, C1-6 alkyl, etc.; or pharmaceutically acceptable salts thereof are provided.
Public/Granted literature
- US20120214790A1 N-ACYL CYCLIC AMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Public/Granted day:2012-08-23
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