A circuit and method are provided to control the strength of signals from an array of photo-detectors (PDs) in an optical navigation sensor. The circuit includes a number of transimpedance-amplifiers (TIAs) each coupled to an output of at least one PD to receive a current signal therefrom and generate a signal in response thereto. A controller coupled to outputs of the TIAs receives the signals and executes an algorithm to adjust gain of a signal processor coupled to the array. In one embodiment, the signal processor includes differential transimpedance-amplifiers (DIFF-TIAs) each including inputs coupled to receive current signals from the array, and the controller outputs a control signal to adjust a time over which the DIFF-TIAs and the TIAs integrate the current signals. Optionally, the signal processor includes gain-amplifiers coupled to the DIFF-TIAs and TIAs, and the controller outputs a signal to adjust gain thereof.