Chaotic oscillator-based random number generation is described. In an example, a circuit includes a negative differential resistance (NDR) device to receive an alternating current (AC) bias. The circuit further includes a capacitance in parallel with the NDR device, the capacitance having a value such that, in response to a direct current (DC) bias applied to the NDR device and the capacitance, a voltage across the capacitance oscillates with a chaotic period. The circuit further includes a random number generator to generate random numbers using samples of the voltage across the capacitance.