A resistance determining system and method for a protection circuit, includes a resistance determining unit. The resistance determining unit interconnects a microcontroller and a digital resistor, where the microcontroller has first setting voltage corresponding to a first voltage threshold for activating the protection circuit, and the microcontroller is capable of receiving and converting a first external voltage input to the protection circuit to be a first converted voltage. The digital resistor includes a first variable resistor having two terminals connected to the respective first terminal and the second terminal. The microcontroller adjusts a resistance of the first variable resistor to be a first threshold resistance if the first converted voltage is substantially equal to the first voltage threshold, and the first resistance is determined to be substantially equal to the first threshold resistance.