A multiple programmable logic controller (PLC) simulation system is provided. The multiple PLC simulation system includes a plurality of personal computers (PCs), each being configured to comprise a different software PLC which is one of a plurality of PLCs implemented as software in an effort to verify a plurality of PLC codes that generate a PLC input signal and a PLC output signal for controlling lines and equipment of an automated manufacturing system; and a simulation device configured to be connected to a plurality of the PCs over a network, and to perform simulation for verification of a plurality of the PLC codes using an input/output model and a graphic model where the input/output model defines as discrete events operation states of the lines and the equipment which are controlled according to the PLC output signals received from a plurality of the software PLCs and PLC input signals in accordance with the operation states, and the graphic model represents graphically motion change of the lines and the equipment in accordance with a change of operation states using pieces of motion graphic data of the lines and the equipment which correspond to the operation states and the graphic model generates PLC input signals including information on the motion change of the lines and the equipment.