- Patent Title: Methods and compositions for CNS delivery of iduronate-2-sulfatase
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Application No.: US13168966Application Date: 2011-06-25
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Publication No.: US08545837B2Publication Date: 2013-10-01
- Inventor: Gaozhong Zhu , Kris Lowe , Zahra Shahrokh , James Christian , Richard Fahmer , Jing Pan , Teresa Leah Wright , Pericles Calias
- Applicant: Gaozhong Zhu , Kris Lowe , Zahra Shahrokh , James Christian , Richard Fahmer , Jing Pan , Teresa Leah Wright , Pericles Calias
- Applicant Address: US MA Lexington
- Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Choate Hall & Stewart, LLP
- Agent Fangli Chen; Justin P. Huddleson
- Main IPC: A61K38/46
- IPC: A61K38/46 ; A61P25/00
Abstract:
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
Public/Granted literature
- US20110318323A1 METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE Public/Granted day:2011-12-29
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