Invention Grant
US08545841B2 Methods and compositions for the treatment of cancers and pathogenic infections
失效
用于治疗癌症和致病性感染的方法和组合物
- Patent Title: Methods and compositions for the treatment of cancers and pathogenic infections
- Patent Title (中): 用于治疗癌症和致病性感染的方法和组合物
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Application No.: US12811646Application Date: 2009-01-05
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Publication No.: US08545841B2Publication Date: 2013-10-01
- Inventor: William A. Dunn , Debra E. Akin , Ann Progulske-Fox , David A. Ostrov
- Applicant: William A. Dunn , Debra E. Akin , Ann Progulske-Fox , David A. Ostrov
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation, Inc.
- Current Assignee: University of Florida Research Foundation, Inc.
- Current Assignee Address: US FL Gainesville
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/US2009/030102 WO 20090105
- International Announcement: WO2009/089147 WO 20090716
- Main IPC: A61K39/00
- IPC: A61K39/00
Abstract:
The subject application provides small compounds that are able to suppress autophagy in various cells. These compounds are useful in augmenting the existing treatments of various cancers and microbial/parasitic infections. Thus, the subject application also provides methods of treating various types of cancers and microbial/parasitic infections. Also provided by the subject application are methods of suppressing the expansion of autophagosomes within cells or individuals and inhibiting the lipidation of autophagy-related protein 8 (Atg8).
Public/Granted literature
- US20100285012A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS AND PATHOGENIC INFECTIONS Public/Granted day:2010-11-11
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