The disclosure relates to sunscreen compositions having a synergistic combination of titanium dioxide filtering agents that provide a high sun protection factor (SPF). Compositions according to the disclosure have high SPF values without requiring high overall amounts of titanium dioxide filtering agents. Also, the sunscreen compositions are less opaque and white than traditional sunscreens making them aesthetically appealing to consumers. Finally, the disclosure relates to methods of using the described compositions for protecting keratinous substances such as skin and hair from UV radiation.