Invention Grant
- Patent Title: Ubiquitin ligase and use thereof
- Patent Title (中): 泛素连接酶及其用途
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Application No.: US13389065Application Date: 2010-08-06
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Publication No.: US08546094B2Publication Date: 2013-10-01
- Inventor: Kazuhiro Iwai
- Applicant: Kazuhiro Iwai
- Applicant Address: JP Osaka
- Assignee: Osaka University
- Current Assignee: Osaka University
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2009-184878 20090807
- International Application: PCT/JP2010/063345 WO 20100806
- International Announcement: WO2011/016540 WO 20110210
- Main IPC: C12Q1/25
- IPC: C12Q1/25 ; C12N9/00
Abstract:
Provided is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified. It was found out that a complex of (a) a protein having a part of HOIP and at least having a UBA region and a RING-IBR-RING region thereof, and (b) One or more kinds of proteins which individually form a complex with the above (a) is a novel ubiquitin ligase which has linear polyubiquitination activity and can be efficiently expressed and purified.
Public/Granted literature
- US20120145544A1 NOVEL UBIQUITIN LIGASE AND USE THEREOF Public/Granted day:2012-06-14
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