Invention Grant
US08546104B2 Processes for the preparation of phosphatide salts 有权
制备磷脂盐的方法

  • Patent Title: Processes for the preparation of phosphatide salts
  • Patent Title (中): 制备磷脂盐的方法
  • Application No.: US12700073
    Application Date: 2010-02-04
  • Publication No.: US08546104B2
    Publication Date: 2013-10-01
  • Inventor: David Rutenberg
  • Applicant: David Rutenberg
  • Applicant Address: IL Haifa
  • Assignee: Lipogen Ltd.
  • Current Assignee: Lipogen Ltd.
  • Current Assignee Address: IL Haifa
  • Agency: FlashPoint IP Ltd.
  • Agent Reuven K. Mouallem
  • Priority: IL193303 20080807
  • Main IPC: C12P1/00
  • IPC: C12P1/00
Processes for the preparation of phosphatide salts
Abstract:
The present invention discloses processes a process for the preparation of phosphatide-salt complexes, the process including the steps of: using at least one raw material lecithin as a substrate; and enzymatically processing at least one raw material lecithin with phospholipase-D, racemic or enantiomerically-pure serine, and/or amine in an aqueous carboxylate-salt-complex solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatide-salt complexes having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed at a pH in the range of about 4.5-8.0 at a temperature in the range of about 25-60° C. Preferably, the aqueous carboxylate-salt-complex solution is formed from an aqueous solution of a carboxylic acid with a chain length of C2-C8 and a salt in an approximately 1:2 (weight per weight) acid-to-salt ratio.
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