Invention Grant
- Patent Title: Compositions and methods for siRNA inhibition of angiogenesis
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Application No.: US11422982Application Date: 2006-06-08
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Publication No.: US08546345B2Publication Date: 2013-10-01
- Inventor: Michael J. Tolentino , Samuel Jotham Reich
- Applicant: Michael J. Tolentino , Samuel Jotham Reich
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pepper Hamilton LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Public/Granted literature
- US20070037761A1 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS Public/Granted day:2007-02-15
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