Invention Grant
- Patent Title: Nanoparticle formulated glycolipid antigens for immunotherapy
- Patent Title (中): 纳米颗粒配制的糖脂抗原用于免疫治疗
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Application No.: US13188642Application Date: 2011-07-22
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Publication No.: US08546371B2Publication Date: 2013-10-01
- Inventor: Dapeng Zhou , Chun Li
- Applicant: Dapeng Zhou , Chun Li
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A61K31/33
Abstract:
A composition for stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells includes a glycolipid antigen and a nanoparticle conjugated with the glycolipid antigen. The glycolipid antigen and the nanoparticle are not antigenic in mouse and human being. The composition can further include covalent or non-covalent connection between the glycolipid antigen and the nanoparticle. The glycolipid antigen is alpha-galactosylceramide or an analog of that. The nanoparticle can be a polymer. A production method of the composition includes preparing a nanoparticle and a glycolipid antigen and loading the glycolipid antigen to the nanoparticle. The glycolipid antigen can be coated onto the surface of the nanoparticle or encapsulated within the nanoparticle. A method of stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells is also provided.
Public/Granted literature
- US20120021050A1 NANOPARTICLE FORMULATED GLYCOLIPID ANTIGENS FOR IMMUNOTHERAPY Public/Granted day:2012-01-26
Information query
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