Invention Grant
- Patent Title: Aminodihydrothiazine derivatives
- Patent Title (中): 氨基二氢噻嗪衍生物
-
Application No.: US13243971Application Date: 2011-09-23
-
Publication No.: US08546380B2Publication Date: 2013-10-01
- Inventor: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
- Applicant: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2005-309642 20051025; JP2006-076636 20060320
- Main IPC: C07D279/00
- IPC: C07D279/00 ; C07D265/00 ; A61K31/535 ; A61K31/541
Abstract:
A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20120022249A1 AMINODIHYDROTHIAZINE DERIVATIVES Public/Granted day:2012-01-26
Information query
