Invention Grant
US08546395B2 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof 有权
(1H-吡咯并[2,3-b]吡啶-4-基)咪唑并[1,2-b]哒嗪衍生物及其治疗用途

  • Patent Title: 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
  • Patent Title (中): (1H-吡咯并[2,3-b]吡啶-4-基)咪唑并[1,2-b]哒嗪衍生物及其治疗用途
  • Application No.: US13128998
    Application Date: 2009-11-30
  • Publication No.: US08546395B2
    Publication Date: 2013-10-01
  • Inventor: Christophe PacaudFrederic Puech
  • Applicant: Christophe PacaudFrederic Puech
  • Applicant Address: FR Paris
  • Assignee: Sanofi
  • Current Assignee: Sanofi
  • Current Assignee Address: FR Paris
  • Agency: Scully, Scott, Murphy & Presser, P.C.
  • Priority: FR0806723 20081201
  • International Application: PCT/FR2009/052336 WO 20091130
  • International Announcement: WO2010/063929 WO 20100610
  • Main IPC: A01N43/58
  • IPC: A01N43/58 A61K31/50 C07D487/00
6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
Abstract:
The invention relates to 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to the general formula (I) in which R2 represents an aryl group optionally substituted with one or more halogen atoms or C1-6-alkyl, C1-6-alkyloxy, C1-6-alkylthio, C1-6-fluoroalkyl, C1-6-fluoroalkyloxy and —CN groups or R2 represents a group chosen from C1-6-alkyl, C1-6-fluoroalkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-6-alkyl groups; A represents a C1-7-alkylene group; B represents a C1-7-alkylene group; L represents either a nitrogen atom optionally substituted with an Rc or Rd group, or a carbon atom substituted with an Re1 group and an Rd group or two Re2 groups; the carbon atoms of A and of B being optionally substituted with one or more Rf groups, which may be identical to or different from one another. Preparation process and therapeutic use.
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