Invention Grant
US08546395B2 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
有权
(1H-吡咯并[2,3-b]吡啶-4-基)咪唑并[1,2-b]哒嗪衍生物及其治疗用途
- Patent Title: 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
- Patent Title (中): (1H-吡咯并[2,3-b]吡啶-4-基)咪唑并[1,2-b]哒嗪衍生物及其治疗用途
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Application No.: US13128998Application Date: 2009-11-30
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Publication No.: US08546395B2Publication Date: 2013-10-01
- Inventor: Christophe Pacaud , Frederic Puech
- Applicant: Christophe Pacaud , Frederic Puech
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: FR0806723 20081201
- International Application: PCT/FR2009/052336 WO 20091130
- International Announcement: WO2010/063929 WO 20100610
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A61K31/50 ; C07D487/00
![6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof](/abs-image/US/2013/10/01/US08546395B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to the general formula (I) in which R2 represents an aryl group optionally substituted with one or more halogen atoms or C1-6-alkyl, C1-6-alkyloxy, C1-6-alkylthio, C1-6-fluoroalkyl, C1-6-fluoroalkyloxy and —CN groups or R2 represents a group chosen from C1-6-alkyl, C1-6-fluoroalkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-6-alkyl groups; A represents a C1-7-alkylene group; B represents a C1-7-alkylene group; L represents either a nitrogen atom optionally substituted with an Rc or Rd group, or a carbon atom substituted with an Re1 group and an Rd group or two Re2 groups; the carbon atoms of A and of B being optionally substituted with one or more Rf groups, which may be identical to or different from one another. Preparation process and therapeutic use.
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