Invention Grant
- Patent Title: Oncogenic-RAS-signal dependent lethal compounds
- Patent Title (中): 致癌RAS信号依赖致死化合物
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Application No.: US12583579Application Date: 2009-08-21
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Publication No.: US08546421B1Publication Date: 2013-10-01
- Inventor: Brent R. Stockwell , Wan Seok Yang , Rohitha Sriramaratnam
- Applicant: Brent R. Stockwell , Wan Seok Yang , Rohitha Sriramaratnam
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Bryan Cave LLP
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D471/04 ; C07D495/04
Abstract:
Compounds with cancer cell specific lethality are provided. In particular, RAS-selective lethal compounds and compositions are provided. Also provided are methods of screening for such compounds and methods of treating a condition in a mammal, by administering to the mammal a therapeutically effective amount of such compounds or compositions.
Public/Granted literature
- US20100081654A1 Oncogenic-RAS-signal dependent lethal compounds Public/Granted day:2010-04-01
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