Invention Grant
US08546526B2 Selective αvβ3 receptor peptide antagonist for therapeutic and diagnostic applications
有权
用于治疗和诊断应用的选择性alphavbeta3受体肽拮抗剂
- Patent Title: Selective αvβ3 receptor peptide antagonist for therapeutic and diagnostic applications
- Patent Title (中): 用于治疗和诊断应用的选择性alphavbeta3受体肽拮抗剂
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Application No.: US12089709Application Date: 2006-10-09
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Publication No.: US08546526B2Publication Date: 2013-10-01
- Inventor: Annarita del Gatto , Laura Zaccaro , Carlo Pedone , Michele Saviano
- Applicant: Annarita del Gatto , Laura Zaccaro , Carlo Pedone , Michele Saviano
- Applicant Address: FR Saint Genis Pouilly
- Assignee: Advanced Accelerator Applications
- Current Assignee: Advanced Accelerator Applications
- Current Assignee Address: FR Saint Genis Pouilly
- Agency: Steinfl & Bruno LLP
- International Application: PCT/EP2006/009733 WO 20061009
- International Announcement: WO2007/042241 WO 20070419
- Main IPC: A61K38/12
- IPC: A61K38/12 ; A61K38/00 ; A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C07K1/00
Abstract:
The present invention is related to new peptide antagonists of αvβ3 receptor, designed on the basis of the crystal structure of integrin αvβ3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the αvβ3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for αvβ3-targeted therapy and imaging.
Public/Granted literature
- US20080213190A1 Selective Alfavbetas Receptor Peptide Antagonist for Therapeutic and Diagnostic Applications Public/Granted day:2008-09-04
Information query
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