Disclosed is a flip-chip semiconductor device having isotropic electrical interconnection, primarily comprising a chip and a substrate. The chip has at least a first bump and a plurality of second bumps. The substrate has a plurality of bump pads disposed on the top surface and an isotropic connecting mechanism disposed inside the substrate consisting of a plurality of terminals electrically isolated from each other and a flexible vertical pad protruded from the top surface, wherein the disposition locations of the terminals circle around the flexible vertical pad as a disposition center. When the second bumps of the chip are bonded onto the corresponding bump pads, the first bump presses and bends the flexible vertical pad in a specific horizontal direction so that the flexible vertical pad selectively and electrically connect to a selected one of the terminals.