An integrated circuit (IC) with an Intellectual Property (IP) protection system is disclosed. The IC includes a memory array operable to store a key. The key is a sequence of binary bits. The IC also has an IP block operable to perform a function. The IP block is defined through the circuitry of the IC. The IP block is also operable to be activated with the key. The IC has an interconnection operable to couple the memory array to the IP block. The interconnection transfers the key from the memory array to the IP block. A method to configure and to operate the IC is also provided.