Compensation is performed for an image capture device which includes an image sensor which has a tunable spectral response and which is tunable in accordance with a capture mask. The compensation is for spatial non-uniformity in color sensitivity of the image sensor. A default capture mask is applied to the image sensor, and a sample image is captured using the image sensor tuned by the default capture mask. Color of the sample image is analyzed to identify spatial non-uniformity in color sensitivity of the image sensor. A compensation capture mask is constructed. The compensation capture mask is constructed using calculations based on the identified spatial non-uniformity so as to compensate for spatial non-uniformity in color sensitivity of the image sensor. The compensation capture mask is stored in a memory of the image capture device for application of the compensation capture mask to the image sensor.